منابع مشابه
Microtubule dynamics.
Microtubules are highly dynamic and switch stochastically between growing and shrinking phases both in vivo and in vitro. This non-equilibrium behavior, known as dynamic instability, is based on the binding and hydrolysis of GTP at the nucleotide exchangeable site (E-site) in β-tubulin. Only dimers that have GTP in their E-site can polymerize (red tubulin subunits), but following polymerization...
متن کاملMicrotubule polymerization dynamics.
The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that can change rapidly in response to cellular needs and, in some cases, to perform mechanical work. Microtubules utilize the energy of GTP hydrolysis to fuel a unique polymerization mechanism termed dynamic instability. In this review,...
متن کاملDynamics of Microtubule Instabilities.
We investigate an idealized model of microtubule dynamics that involves: (i) attachment of guanosine triphosphate (GTP) at rate λ, (ii) conversion of GTP to guanosine diphosphate (GDP) at rate 1, and (iii) detachment of GDP at rate μ. As a function of these rates, a microtubule can grow steadily or its length can fluctuate wildly. For μ = 0, we find the exact tubule and GTP cap length distribut...
متن کاملMeasuring microtubule thickness: an exercise in cooperativity.
Doublecortin (DCX), a microtubule-associated protein, is essential for neuronal migration, although a clear mechanistic understanding of this requirement remains elusive. In this issue of Developmental Cell, Bechstedt and Brouhard (2012) report that DCX relies on cooperative binding and an affinity for growing microtubule ends to nucleate and stabilize 13-protofilament microtubules.
متن کاملMeasuring Nanometer Scale Gradients in Spindle Microtubule Dynamics Using Model Convolution Microscopy□D □V
A computational model for the budding yeast mitotic spindle predicts a spatial gradient in tubulin turnover that is produced by kinetochore-attached microtubule (kMT) plus-end polymerization and depolymerization dynamics. However, kMTs in yeast are often much shorter than the resolution limit of the light microscope, making visualization of this gradient difficult. To overcome this limitation, ...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2018
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20180035